Funding tool: Basic research projects
Project-ID: LSC20-017
Project start: 01. April 2022
Project end: will follow
Runtime: 36 months / ongoing
Funding amount: € 199.720,00

Brief summary:
Background Osteoarthritis (OA) is the most prevalent arthritic disease worldwide characterized by pain, effusion and stiffness leading to functional decline and reduced quality of life (QL). It has been long considered as a degenerative disease of cartilage resulting from bodily wear and tear that affect the entire joint structure. However, there is accumulating evidence that inflammation plays a key role in the OA pathogenesis. Triggered from tissue damage and by metabolic dysfunction, inflammatory processes within the joint may trigger the development of chronic low-grade inflammation. Factors that contribute to chronic low-grade inflammation include a nutrient overload, a metabolic surplus, pro-inflammatory cytokines and adipokines. Knee OA is the most common form of OA with prevalence rising with age peaked at around 50 years of age affecting more than 250 million people worldwide. Exercise therapy (ET) is an effective component of early treatment and is therefore recommended as a first line treatment. Good Life with osteoArthritis in Denmark (GLA:D®) represents an evidence-based treatment plan for knee OA and optimizes the implementation of ET. However, ET mainly addresses physical and functional deficits in patients with knee OA, but not the inflammatory processes. Due to the association of chronic low-grad inflammation with dietary patterns, nutrition plays a significant role in inflammation-related diseases. A plant-based, anti-oxidative and anti-inflammatory therapeutic diet helps to improve symptoms leading to improved quality of life. When implementing a therapeutic diet, it should be attractive for patients and regional needs should be considered. This might increase adherence to therapeutic diet and will have an environmental impact - the New Nordic Diet (NND) seems to fulfil these requirements. To our knowledge no study has examined the influence of NND on symptoms and QL in OA. Further, there is a lack of knowledge concerning the impact of exercise therapy AND nutrition therapy on symptoms and QL in patients with knee OA. Aims 1. To evaluate the effect of a nutrition therapy combined with exercise therapy on QL in patients knee OA 2. To investigate the impact of a nutrition therapy combined with exercise therapy on symptoms, nutrition and inflammation status and joint function in patients with knee OA Methods A total of 60 participants aged between 50 and 75 years with knee OA will be included and randomly assigned to the intervention/control group. The intervention group receive the GLA:D® training program for 6 weeks and a nutrition therapy for 9 months. The control group receive GLA:D® training program for 6 weeks and general information regarding a healthy life style for 9 months. Measurements at baseline and 4 follow-ups include biochemical, nutritional and oxidative stress parameters as well as inflammation biomarkers. Further, anthropometric and behavioural parameters and clinical data will be measured.