Stereoselektive molekulare Erkennungsmaterialien
University of Natural Resources and Life Sciences, Vienna
Hubert Hettegger (University of Natural Resources and Life Sciences, Vienna)
Georg Sixta (IMC University of Applied Sciences Krems)
Project start: 01. November 2021
Runtime: 36 months / ongoing
Funding amount: € 269.072,00
Brief summaryIn this research project, innovative materials for the separation and analysis of chiral compounds based on high-performance liquid chromatography (HPLC) will be developed and evaluated. The research work is thematically located at the interface between organic and analytical chemistry, chemistry of renewable raw materials (cellulose and other polysaccharides) and in the field of pharmaceutical analysis. The separation of chiral compounds into the respective enantiomers is an omnipresent analytical and preparative challenge in medical, pharmaceutical and chemical disciplines. This, for example, applies to the production and purity determination of chiral drugs (e.g. ibuprofen), the pharmacokinetic profiling of optically active pharmaceuticals in both human and veterinary medicine, as well as the investigation of food contaminants (e.g. mycotoxins) and environmental pollutants (e.g. chiral fungicides and pesticides). The most common method here is direct chiral HPLC. A large number of HPLC column materials based on a wide variety of chiral selectors is already commercially available, with polysaccharide-based silica gel hybrid phases having emerged as the most powerful ones. However, these are only available in neutral form. Chiral compounds also contain acidic and basic molecular structural motifs and are therefore often present in the respective ionized forms as organic salts. The aim of the project is thus to develop novel chiral ion-exchange separation phases based on polysaccharide derivatives and their inorganic hybrids, which can be used in the above-mentioned disciplines for the separation of chiral organic acids and bases that were previously impossible or at least difficult to separate. The underlying molecular recognition mechanisms and separation parameters will be investigated in detail as well.